Tyler Lyons earned a win in his major league debut after allowing one run and four hits in seven innings Wednesday against the Padres.
Tim Stauffer pitched 5 2/3 innings in relief Wednesday, allowing one run and striking out seven Cardinals.
Burch Smith lasted just one-plus innings Wednesday and gave up four runs in a loss to the Cardinals.
Yadier Molina had four of the Cardinals' 14 hits in Wednesday's win over the Padres.
Jedd Gyorko went 2-for-4 and hit his fifth homer Wednesday versus the Cardinals.
Brayan Pena went 3-for-5 with an RBI and a run scored in the Tigers' 11-7 victory over the Indians on Wednesday.
Carlos Santana went 2-for-4 with a home run in the loss to the Tigers on Wednesday.
Michael Brantley went 3-for-5 with three RBI in the Indians' loss to the Tigers on Wednesday.