Dejan Lovren scored the only goal Southampton would need to take 3 points on the road and hand Liverpool their first defeat 0-1.
Boaz Myhill and West Brom surprised Liverpool at the Hawthorns as the keeper made five saves and kept a clean sheet in the nil-nil draw.
QPR's hopes of avoiding relegation from the Premier League were hit as Charlie Austin missed a penalty as they could only draw at home against West Ham.
It wasn't a scintillating match but Simon Mignolet made a key save on James Morrison when it counted to keep Liverpool even in the nil-nil draw at the Hawthorns.
Swansea City received a huge performance from Nelson Oliveira as they became the latest club to beat up on Newcastle United with a 2-3 win at St. James' Park.
Charlie Adam scored another great goal to equalize an early Sunderland goal and seal the final score between Stoke City and Sunderland at 1-1.
Connor Wickham scored in the first minute but Sunderland were dominated for the rest of the match and dropped into the relegation zone after having to settle for a 1-1 draw.
Jamie Vardy scrambled a winner to lift Leicester out of the Premier League relegation zone just seconds after bottom club Burnley missed a penalty.
Graziano Pelle was sharp for Southampton today, scoring twice, but the Saints would allow Tottenham to erase two leads as the battle for fifth place ended in a 2-2 draw.
Tottenham erased 1-0 and 2-1 deficits to earn a point at St. Mary's in a 2-2 final against Southampton.
Wayne Routledge has been ruled out for the remainder of this campaign after surgery to cure an ongoing and persistent ankle problem.
Hull City boosted their chances of avoiding relegation as Dame N'Doye scored both goals in a hard-earned 2-0 win at Crystal Palace.