Fernando Llorente scored a goal that appeared to be from an offside position as Spurs beat Swansea in a downpour at the Liberty Stadium on Tuesday.
Mark Hughes welcomes Steven Davis back into the fold after more than two months, but the Saints travel to Leicester City without Mario Lemina and Sofiane Boufal.
Jack Wilshere faces a late fitness test after missing the 2-1 defeat at Newcastle last weekend because of injury.
The Belgian forward was 9n the bench to start but came in to put away United's 2-0 win over Bournemouth.
Sergio Aguero's arthroscopic surgery could have more repercussions that just the end of the Premier League season.
Adam Lallana is going global in an attempt to fast-track his recovery from a hamstring related problem.
Renato Sanches has returned to South Wales and he is determined to play a part in Swansea’s final push for Premier League survival.
Shinji Okazaki and Kasper Schmeichel will be assessed ahead of game with Southampton.
Brighton fought hard against Spurs at the AMEX and emerged with a creditable 1-1 draw.
Sergio Aguero is expected to miss the remainder of the season following a small surgical procedure on his knee.
Manchester United manager José Mourinho is set to drop a number of first team players after Sunday's 1-0 loss to bottom side West Brom.
Substitute Andy Carroll's late equalizer earned West Ham a point in Monday's 1-1 draw against Stoke City.