Having already been labeled a doubt earlier in the week, Arouna Kone has been officially ruled out by Roberto Martinez for Everton's match against Tottenham Hotspur.
Celtic Football Club have announced that they have secured the signing of Manchester United defender Tyler Blackett on loan for the 2015-16 season.
Raheem Sterling got his first goal for Manchester City from a Bacary Sagna assist as the league leaders beat Watford 2-0 at the Etihad.
Heurelho Gomes and the Watford defense made a valiant effort for the first half but couldn't keep the City attack at bay for the entire 90 minutes and capitulated at the Etihad in Week 4 action.
Ibrahim Afellay was baited into a sending-off offense and Charlie Adam followed as Stoke City lost at home to former manager Tony Pulis at the Britannia.
Salomon Rondon scored and Stoke City had two men sent off as Tony Pulis led his Baggies to victory at his old Stoke City stomping grounds.
Alex Oxlade-Chamberlain didn't get credit for the goal but he caused it to go in off of Fabricio Coloccini for the only goal in Arsenal's 1-0 win against Newcastle at St. James' Park.
Fabricio Coloccini added to Newcastle's difficult start to the season with an own goal as Newcastle dropped a decision at home to Arsenal in Week 4 action.
After seeing yellow within moments of being introduced in his first two Newcastle matches, Mitrovic upped the ante to a red card after 16 minutes in Week 4.
David De Gea will continue to watch on from afar as Manchester United attempts to decide his short and long term fate. Sergio Romero will deputize again at the Liberty Stadium.
Marcos Rojo will make the squad for a Premier League match for the first time this season as United travel to Wales for a Week 4 match against last season's tormentors Swansea.
Gael Clichy's prognosis had been a bit murky thus far but Manuel Pelligrini clarified this week that the left back would be out another six or seven weeks.