Chelsea were defeated 0-2 by underdogs Newcastle United, missing their chance to go at least temporarily top of the Premier League table.
Jordon Ibe has been ruled out for between 3-4 weeks after the Liverpool youngster damaged lateral knee ligaments during last Thursdays’ Europa League game against Besiktas.
Christian Benteke's last-gasp penalty gave Tim Sherwood his first points as Aston Villa manager with victory over West Brom at Villa Park.
Saido Berahino's goal wasn't enough for West Brom as they went down to a last minute defeat at rivals Aston Villa.
Dame N'Doye returned to the Hull City starting line-up in Week 28 and made a major impact but couldn't power his team to victory as they drew with Sunderland 1-1.
A Sadio Mane late goal gave Southampton three points over Crystal Palace.
Jack Rodwell was in the middle of just about everything as Sunderland came from a goal down to draw 1-1 with Hull City at the KC Stadium.
Francis Coquelin is questionable for Arsenal's trip across London after suffering a head injury in a collision with Olivier Giroud in the 2-0 over Everton on Sunday.
After being rested for Week 27 against Everton, Per Mertesacker may be rested again for Week 28 in order to give him an extended rest.
Phil Jones missed the visit of Sunderland over the weekend with an illness but should be ready to go again for the mid-week trip to St. James' Park.
Jon Walters' ongoing knee issues may keep him out of Stoke City's Wednesday match with Everton in Week 28.
Kieran Richardson and Aly Cissokho will both miss out on a second consecutive match as Aston Villa host Midlands rivals West Brom on Tuesday.