Wojciech Szczesny injured his ankle in training with the Polish national side.
Francis Coquelin is questionable for Arsenal's trip across London after suffering a head injury in a collision with Olivier Giroud in the 2-0 over Everton on Sunday.
After being rested for Week 27 against Everton, Per Mertesacker may be rested again for Week 28 in order to give him an extended rest.
Phil Jones missed the visit of Sunderland over the weekend with an illness but should be ready to go again for the mid-week trip to St. James' Park.
Jon Walters' ongoing knee issues may keep him out of Stoke City's Wednesday match with Everton in Week 28.
Kieran Richardson and Aly Cissokho will both miss out on a second consecutive match as Aston Villa host Midlands rivals West Brom on Tuesday.
Dame N'Doye was rested due to fatigue after having to travel back and forth to Senegal last week. He is questionable for Week 28 but seems likely to play having had two more days to recover.
Crystal Palace midfielder Mile Jedinak has accepted a Football Association charge of violent conduct after elbowing West Ham's Diafra Sakho.
Massadio Haidara suffered a setback in training and is highly unlikely to feature for Newcastle United tomorrow evening when they host Manchester United.
Saido Berahino played and scored over the weekend after being questionable but is listed as questionable again for Albion's mid-week at rivals Aston Villa.
Nikica Jelavic who missed Hull City's Week 27 loss has a chance to feature in Week 28 with his manager saying that he's "hopeful".
Graziano Pelle could lose his starting job after a series of horrible performances.