Everton boss Roberto Martinez gave an update on Leighton Baines' status in his recent press conference, stating the left back was making good progress with his toe injury, but could not provide a timetable for his return, going so far as to say Baines may not be ready until the New Year.
When Jonny Evans went down with a hamstring strain against Swansea in Week 24, Tony Pulis chose to use Craig Gardner rather than James Chester despite Chester being the only recognized center back on the bench.
Chris Brunt joins James Morrison and Jonny Evans on the sidelines as West Brom travel to Newcastle in Week 25 Premier League action.
Kevin Mbabu has returned to the Newcastle United squad following a thigh injury that saw him sit out the month of January, and may need to step in immediately as an emergency left back.
Phil Jones is getting close to a return but won't be back in time to ease Manchester United's defensive injury crisis for their match with Chelsea.
Marouane Fellaini's ability to feature on Sunday against Chelsea is in question after he picked up a knock against Stoke City in midweek.
Etienne Capoue has been a rock for Watford this season but he will have to race against time to recover from illness in time to feature at White Hart Lane on Saturday.
Record signing Gianelli Imbula has been officially registered and could get his first start for the Potters against Everton in Week 25.
Philipp Wollscheid is questionable for Week 25 with a calf injury and will join Ryan Shawcross, Marc Wilson and Geoff Cameron on the sidelines if he can't recover in time.
Jonny Evans joins a growing list of injuries for West Brom as the Baggies continue to drop down the table.
Paul Dummett will miss Newcastle United's match with West Bromwich Albion tomorrow as the defender has failed to recover from a hamstring injury.
Newcastle United have been dealt yet another major injury blow as starting center back Chancel Mbemba will miss tomorrow's match against West Bromwich Albion with an ankle issue, and likely miss further time.