Gerard Deulofeu's hamstring injury was confirmed by the Everton medical staff, and a five week convalescence is expected.
Grazianno Pelle and Steven Davis are both suffering from fatigue and are at risk of being rested on Sunday.
Ryan Bertrand is unavailable for week 19 due to a clause in his contract preventing him from playing against his parent club.
Connor Wickham returns from suspension in week 18 and will be available to face Aston Villa.
Manchester City forward Stevan Jovetic could feature in GW19 after being an unused substitute on Boxing Day.
Everton goalkeeper Joel Robles is likely to start on Sunday against Newcastle due to the injury to American goalkeeper Tim Howard.
Steven Naismith will serve a one-match ban during gameweek 19 for accumulation of yellow cards.
Fraizer Campbell picked up a knock on Boxing Day and is at risk to missing the week 19 match at QPR.
Kyle Walker is a high risk to be rested on Sunday after missing nine months to injury.
Hugo Lloris is expected to play on Sunday after he went through a scare of a concussion.
Leicester forward Jamie Vardy is suspended for gameweek 19 due to accumulating five yellow cards.
Cheik Tiote is expected to return to Newcastle's lineup in week 19 after serving a one-match ban.