Arsenal continues to be without key reserves as Thomas Vermaelen joins Mikel Arteta, Thomas Rosicky, Nacho Monreal, and Nicklas Bendtner in being unavailable for the Fulham match.
Chelsea have been handed a double boost with the news that Pedro and Tiemoue Bakayoko will be available for Saturday's visit from Stoke City.
Christian Fuchs will be fit to face Liverpool on Saturday after recovering from a "freak" eye injury he picked up in training.
Leicester City manager Craig Shakespeare confirmed Jamie Vardy's availability would be assessed ahead of Saturday's match against Liverpool.
Matty James will miss out on Sunday's match against Liverpool after being ruled out for four to six weeks with an Achilles injury.
Manchester City manager Pep Guardiola confirmed that Vincent Kompany is in line to return this weekend.
Newcastle will have to do without two key defenders once again with Paul Dummett and Florian Lejeune still out.
Crystal Palace is nearing the end of its anxious wait without Wilfried Zaha with the winger close to a return.
Chris Brunt continues to be a difficult player to get a handle on between a current calf issue and where Kieran Gibbs fits into the picture.
Geoff Cameron's continuing hamstring issues piles on the misery for Mark Hughes who is going to struggle to field a defense against visiting Chelsea.
Kurt Zouma won't be able to play against parent club Chelsea in Week 6 action per the terms of his loan deal.
Marco Silva's defense gets a boost with the return of Kiko Femenia after the right back was taken off in Week 5 due to a head injury.