Jay Rodriguez and Dejan Lovern both scored pretty goals to put Southampton up 2-0 but they couldn't hold the lead and had to settle for a draw at the Stadium of Light.
Arsenal were listless in attack and required their goalkeeper to come to the rescue on three strong Boro chances in the first half.
Liverpool were in the ascendancy for the majority of the clash with West Brom at Anfield but should have converted more of their chances.
David Moyes' Sunderland crumbled at the death to give West Ham a deserved win at the Olympic Stadium.
Crystal Palace fans will be asking themselves how they ended up playing last year's Leicester City in a 3-1 loss to the Premier League champions.
Bob Bradley shook up his Starting XI and Swansea had chances to give the new manager his first win, but they were only able to give him his first point in a 0-0 draw with Watford.
Leicester City ended a crippling three-match Premier League winless streak with a 3-1 win against Crystal Palace at the King Power.
Watford put forth another solid defensive display and were able to pick up a point on the road, playing Swansea City to a 0-0 draw.
Burnley winger Scott Arfield brought the Turf Moor to life in the 90th minute with his last-ditch match-winner in a 2-1 win against Everton.
Junior Stanislas and Andrew Surman were both omitted from Eddie Howe's starting line-up for the game at home to unbeaten Spurs.
Tottenham maintain their unbeaten record on the season but were also held goalless for the first time in league play as they could not find an answer against AFC Bournemouth in a 0-0 final at Vitality Stadium.
AFC Bournemouth continue to build on a solid record at home, becoming the first Premier League side to keep Tottenham from scoring this season as the two sides play to a goalless draw.