Phil Jones will miss Manchester United's trip to the Emirates with a calf injury.
With Alex Oxlade-Chamberlain playing very well as the primary right-sided wing-back/outside midfielder in Arsene Wenger's 3-4-3 there is an open question about what becomes of Hector Bellerin.
Ryan Bertrand scored a late goal against former club Chelsea but it wasn't nearly enough as the Blues beat the Saints 4-2 at Stamford Bridge on Tuesday.
Diego Costa scored a brace as Chelsea won a critical match in the title race over Southampton 4-2.
Victor Valdes is the only expected injury absentee for Middlesbrough who face north east rivals Sunderland at the Riverside on Wednesday.
Mamadou Sakho is poised to return against Tottenham on Wednesday evening as James Tomkins is set for a spell on the sidelines.
Hull City striker Oumar Niasse's appeal against a three match ban incurred after his sending off last weekend has been successful.
Southampton manager Claude Puel has indicated that he hopes to change the culture at St Mary's of selling key players in the summer transfer window.
Southampton manager Claude Puel has said that he cannot guarantee that new signing Martin Caceres will make his Saints debut this season.
Manchester United appear to be edging closer to signing Atlético Madrid striker Antoine Griezmann in the summer.
Manchester United are rumoured to be confident of signing Burnley centre-back Michael Keane, who is a product of United's academy.
Having failed in their bid to land centre-back Michael Keane in January, Everton have now refocused their efforts on Hull City's Harry Maguire.