Jermain Defoe will miss the opportunity to make his farewell appearance for Tottenham against Dnipro in the Europa League because of a hamstring injury.
Yaya Toure was uninspiring for the third week in a row and finished with negative two fantasy points in Manchester City's 1-0 loss to Stoke.
The Baggies conceded early and often at the Liberty Stadium as they fell for the first time this season.
Grazianno Pelle scored to help Southampton to a 3-1 win over West Ham United.
Swansea's dream start to the season continued with an easy 3-0 win over West Brom that featured a Nathan Dyer brace.
Stoke forward Mame Biram Diouf slotted home a spectacular solo goal in the second half that was enough for his side to defeat Manchester City 1-0.
Charlie Austin scored the only goal of the game as Queens Park Rangers grabbed their first points of the season.
In an enjoyable contest where the lead changed hands, the standout performer for Newcastle United was Rolando Aarons, an 18 year old prospect who notched a goal and an assist as a substitute as the Magpies played Crystal Palace to a 3-3 draw.
Burnley turned in a positive defensive display and went toe to toe with Manchester United to earn their first point of the season in a 0-0 final.
Angel Di Maria was thrust immediately into Manchester United's starting XI and showed some promising displays but United as a unit once again failed to impress both attacking and defending, settling for a 0-0 against Burnley.
Stephen Ireland will be held out of the Stoke City squad for Week 3 as he nurses a rib injury back to health.
Jonny Evans returned to active duty against MK Dons this week and will likely eye a return to league action this weekend against Burnley