Fernando Torres hurt his groin during warm-ups and was pulled out of Chelsea's match against Tottenham on Saturday.
Wayne Rooney missed out again as Manchester United edged past their rivals City 1-0 at Old Trafford to progress to the quarter-finals of the EFL Cup.
A near full strength Manchester United side overcame a quite rotated Manchester City at Old Trafford in the EFL Cup tonight.
Sofiane Boufal's sensational strike from the left hand side of the top of the box was the difference as Southampton overcame Sunderland in the EFL Cup.
James McCarthy is facing another spell on the sidelines after suffering a hamstring injury during training.
With rotation rampant among both sides, it was Liverpool who showed more quality in their depth as a Daniel Sturridge brace saw the Reds knock Tottenham out of the EFL Cup with a 2-1 win.
Manchester United central defender Eric Bailly is targeting a return to action in December after tests revealed his knee injury is not as bad as originally thought.
Chuba Akpom could be side-lined until the new year if the latest report from the Independent newspaper proves to be accurate.
Chelsea is slowly seeing its defense return to full strength after veterans Branislav Ivanovic and John Terry were passed fit.
Alex Oxlade-Chamberlain scored a goal on either half of the interval as Arsenal beat Reading 2-0 at the Emirates.
Arsenal returned Carl Jenkinson to the starting line-up against Reading in EFL Cup action on Tuesday but Olivier Giroud was only fit enough for the bench.
Hull City have confirmed via their official Twitter account that their Scottish midfielder Robert Snodgrass will be out of action for up to four weeks.