Ryan Giggs and Rio Ferdinand have been recalled to David Moyes' starting line-up as the Red Devils look to avoid further embarrassment and overturn Olympiokos' 2-0 first leg lead.
Pedro has been poor value for the money this season but rebounded with a brace as Chelsea pounded Newcastle 5-1 at Stamford Bridge.
Newcastle will be miserable after dropping a 5-1 decision at Stamford Bridge but at least Andros Townsend got his first goal for the club.
Shane Long scored once again for Southampton and earned his team a huge three points.
Sadio Mane and Dusan Tadic have been relegated to bench roles as Southampton continue playing well.
Graziano Pelle started ahead of Charlie Austin today but did not score in his 74 minutes on the pitch.
John Terry suffered a muscular injury in Chelsea's huge win over Newcastle today and is questionable for the upcoming match against Paris Saint-Germain.
Matteo Darmian will be missing for "several weeks" after Louis van Gaal confirmed the full-back had dislocated his shoulder following a first half collision with Sunderland midfielder Wahbi Khazri.
Seb Larsson could make his long awaited return to first team action in game week twenty-seven after Sam Allardyce confirmed the midfielder re-joined the group in training on Thursday.
It looks like Troy Deeney's rest last weekend has paid dividends for Watford as the captain scored both goals in the club's 2-1 win against struggling Crystal Palace.
Dimitri Payet scored and assisted to help West Ham United earn a point against Norwich City today.
Gianelli Imbula scored his first goal for Stoke City as the Potters finally got out of a scoring drought with a convincing 1-3 win over AFC Bournemouth.