With their top flight status on the line, Cardiff City were hit with a poorly timed illness in their clubhouse, which is why Gary Medel, Kevin Theophile-Catherine and Mats Moller Daehli did not make the squad in their loss to Newcastle United.
After a delay of several weeks, the FA have punished Joey Barton with an 18-month ban for his decade-long gambling offenses.
Tottenham kept their title hopes alive with a hard-fought 1-0 victory at Crystal Palace thanks to Christian Eriksen's superb 78th-minute strike.
Sunderland sit on the brink of relegation after Wednesday's 1-0 lose to Middlesbrough in the Tees-Wear derby.
Arsenal left it late but Nacho Monreal bounced a shot off of Robert Huth and past Peter Schmeichel as the Gunners beat Leicester City 1-0 at the Emirates.
Robert Huth couldn't get out of the way of Nacho Monreal's shot and the deflection, ruled an own goal, ended up as the only goal of the match.
Jose Mourinho provided a mixed update ahead of Thursday’s Manchester derby with Paul Pogba set to miss out because of injury.
David Silva seems certain to miss tomorrow’s Manchester derby having failed to recover the knock which forced him off at Wembley.
With Alex Oxlade-Chamberlain playing very well as the primary right-sided wing-back/outside midfielder in Arsene Wenger's 3-4-3 there is an open question about what becomes of Hector Bellerin.
Ryan Bertrand scored a late goal against former club Chelsea but it wasn't nearly enough as the Blues beat the Saints 4-2 at Stamford Bridge on Tuesday.
Diego Costa scored a brace as Chelsea won a critical match in the title race over Southampton 4-2.
Victor Valdes is the only expected injury absentee for Middlesbrough who face north east rivals Sunderland at the Riverside on Wednesday.