Swansea, absent from European competition since the early '90s, returned with a resounding 4-0 win against Malmo FF that saw Michu score the winner.
Aaron Ramsey scored a goal and registered an assist in Arsenal's 3-0 win over Hull City.
Liverpool opened up a five-point lead at the top of the Premier League after a hard-fought 3-2 victory at Norwich.
Jose Mourinho was handed his first ever loss at Stamford Bridge as manager of Chelsea, as last place Sunderland pulled off the upset of the season in a 1-2 final.
After what until now has been a quiet and disappointing first season in the Premier League, US international Jozy Altidore won a penalty for Sunderland which resulted in the game winning goal as the Black Cats pulled off a huge 1-2 upset over Chelsea.
Kieran Gibbs will miss yet another Arsenal match due to injury with the ankle injury that kept him out of the Everton and West Ham matches persisting for one more week.
Rafael's hamstring injury has persisted with the right back to miss Manchester United's match with Champions League hopefuls Everton.
Christian Eriksen registered two assists, both from set pieces, to help propel Tottenham over Fulham 3-1.
Steve Sidwell added to his team leading goal total by scoring his seventh of the season today, but it was not enough to get a positive result as Fulham lost to Tottenham 3-1.
Mile Jedinak converted a penalty drawn by Cameron Jerome for the only goal in Crystal Palace's 1-0 win against West Ham United at the Boleyn Ground.
Pablo Armero failed to take advantage of his starting opportunity as he was at fault in the match's key moment as he conceded a penalty to Cameron Jerome that Mile Jedinak conceded.
Brad Guzan kept a clean sheet on way to a 0-0 draw against Southampton.