Astros optioned RHPs Jarred Cosart, Jose Cisnero and Ross Seaton and LHP Brett Oberholtzer to Triple-A Oklahoma City.
Dilson Herrera went 3-for-3 with an RBI single and a two-run home run as the Mets topped the Orioles on Wednesday.
Evan Drellich of the Houston Chronicle reports George Springer is expected to be placed on the 15-day disabled list Thursday.
Mike Leake fired eight shutout innings to pick up his second win of the season on Wednesday against the Pirates.
Joey Votto was ejected from Wednesday's game against the Pirates for spiking his helmet.
Ian Kennedy held the Giants to one run over seven innings in the Padres' lopsided 9-1 win Wednesday.
Nick Cafardo of the Boston Globe reports Jarrod Saltalamacchia could sign with a club as early as Thursday.
Corey Dickerson (foot) is out of the Rockies' lineup for the second game of Wednesday's doubleheader against the Diamondbacks.
Yasiel Puig (hamstring) will serve as the designated hitter for High-A Rancho Cucamonga on Thursday.
Stephen Strasburg (shoulder) played catch Wednesday after leaving Tuesday's start with an apparent injury.
Jake McGee (elbow) is scheduled to pitch for Triple-A Durham on Friday.
Sean Doolittle (shoulder) will face live hitters Friday.