La'Rod Stephens-Howling (hip) participated in Wednesday's practice, and "believes he will play" against the Bills.
49ers waived LE Ray McDonald.
Coach Mike Smith said the Falcons will decide Julio Jones' (hip) Week 16 status on Sunday morning.
Cam Newton (back) returned to a limited practice Wednesday.
49ers LE Ray McDonald is being investigated by the San Jose Police Department on a rape allegation that was reported last Tuesday.
Blake Bortles (foot) is questionable for Thursday night's Week 16 game against the Titans but is expected to start.
DeMarco Murray (hand) participated in Wednesday's practice.
T.Y. Hilton (hamstring) is not practicing Wednesday.
Dexter McCluster (knee) has been ruled out for Week 16 against the Jaguars and is expected to miss the rest of the season.
Rashad Jennings (ankle) is not practicing Wednesday.
The Chargers announced Tuesday a commitment to continue new stadium efforts in San Diego through 2015.
Frank Gore (concussion) and Carlos Hyde (ankle, back) both did not practice Tuesday.