Rookie Scott Laughton will fill in for the injured Daniel Briere and center the Flyers' third line featuring Wayne Simmonds and Matt Read.
Sean Couturier will miss the next four weeks with a lower-body injury.
Ben Scrivens is expected to get the nod against Edmonton on Saturday.
Coach Lindy Ruff said that Jason Spezza suffered an upper-body injury Thursday night.
And just like that, Ryan Getzlaf is on a four game point streak.
David Perron is on fire with the Anaheim Ducks.
With his trio of assists on Thursday's night, Artemi Panarin picked up his sixth three-point game of the season.
Antti Niemi won his 20th game of the season in Thursday's 4-3 overtime win over Colorado.
Jordan Eberle led the potent Edmonton Oilers offence on Thursday night with two goals and an assist in their 7-2 victory over Ottawa.
Steve Mason steered the Flyers over the Predators on Thursday night, making 37 saves to lead his team to a 6-3 victory.
Minnesota native Ryan McDonagh scored a goal and added an assist to push the Rangers past the Wild 4-2 on Thursday night.
Joonas Korpisalo will be Columbus' starter on Thursday.