Fernando Torres started but failed to score again and Jose Mourinho was disappointed at his team's failure to convert chances.
Sunderland took the lead with the first goal of the game thanks to Adam Johnson, but the Black Cats surrendered twice and failed to come away with any points in a 1-2 loss.
Andre Schurrle scored twice in Chelsea's loss to Stoke City but left the game with a calf injury.
After trailing 1-0, Paulinho brought Tottenham back level with a goal just before halftime and Spurs completed the comeback thanks to a Sunderland own goal in the second half to win 1-2.
Cardiff City dropped valuable points against Crystal Palace as they creep closer toward the relegation zone after a 2-0 loss at Selhurst Park.
Marouane Chamakh scored for the second consecutive game and Crystal Palace earned their second consecutive win, defeating fellow promoted side Cardiff City 2-0.
West Ham United were undone today by own goals and a red card for a nasty challenge by Kevin Nolan and the Hammers were put away by Liverpool 4-1.
In a game riddled with own goals Luis Suarez managed to tally a no-doubt intended goal, his 14th of the season, and Liverpool win at home 4-1.
Stephane Sessegnon made his way back into the starting XI for West Bromwich Albion after riding the bench midweek but the Baggies could not find the net and fell 0-2.
Leroy Fer was the man for Norwich City today, providing a goal and an assist, and the Canaries were able to keep West Brom out in a 0-2 final.
Oussama Assaidi stunned Chelsea with a late last minute goal to give Stoke City a 3-2 win.
Daniel Osvaldo scored a fantastic goal to give Southampton a point at home against Manchester City.
Robin van Persie was able to work up enough fitness to make the start for Manchester United, but the Red Devils didn't have an answer to penetrate Newcastle's goal and they suffered their second consecutive defeat 0-1.
Yohan Cabaye was the talisman for Newcastle United today, scoring in the 61st minute to put them ahead, and the Magpies held the lead for the final half hour to complete the 0-1 upset and grab three points from Old Trafford.
David Luiz is still out with a knee injury and will miss Chelsea's trip to Stoke City.