Glen Johnson is battling an illness that could see him miss the squad when Liverpool host Manchester City on Sunday.
Roberto Martinez has ruled Christian Atsu out of contention for Everton's trip to the Emirates on Sunday due to an illness, but expects to have him back for the midweek round.
With Andy Carroll and Carlton Cole both absent, Nene will likely be involved in West Ham's match with Crystal Palace at Upton Park on Saturday.
Aston Villa's defensive crisis is at an epic stage with no fewer than six defenders potentially missing out on Saturday's trip to Newcastle including Alan Hutton.
Aly Cissokho could compound Aston Villa's defensive issues if he isn't able to recover from a knock in time to face Newcastle on Saturday.
Kieran Richardson limped off late in the first half of Aston Villa's Week 26 defeat to Stoke City and will not be ready in time for their Week 27 trip to Newcastle.
Aaron Ramsey will likely have trained fully on today by the time this is posted but despite the positive progress he is highly unlikely to be ready for Arsenal's match with Everton on Sunday.
Jack Wilshere will miss at least Arsenal's Week 27 and 28 matches after he had a minor procedure on his ankle.
Sunderland will be without some key players ahead of the trip to Old Trafford in Week 27.
Manuel Pellegrini confirmed Manchester City have a clean bill of health ahead of the Week 27 clash with Liverpool
Romelu Lukaku came off early in the second half of Everton's Europa League win on Thursday but should be fine for the weekend according to manager Roberto Martinez.
Mamadou Sakho has returned to training for Liverpool ahead of the club's Week 27 match with Manchester City at Anfield.
Jordan Henderson, left out of the side that traveled to Turkey for the Europa Cup, will be assessed ahead of Liverpool's big clash with Manchester City in Week 27.
Daryl Janmaat has been passed fit for Week 27 after picking up a knock against Manchester City in Week 26.
Jonas Gutierrez, out for a year and a half battling testicular cancer, could make his return to the Newcastle squad in Week 27.