Younes Kaboul was sent off for a tackle on Samuel Eto'o that resulted in a Chelsea penalty.
Chelsea destroyed Tottenham in a 4-0 game that saw a series of questionable calls from referee Michael Oliver.
Cardiff City boosted their hopes of Premier League survival with a 3-1 victory over Fulham.
Stoke forward had a busy day as he scored the goal that pulled Stoke even and was then shown a red card for a high tackle on Alex Tettey.
Bradley Johnson scored a 56th minute goal to put Norwich City up 1-0 over visiting Stoke but a penalty from Jon Walters saw the match end in a draw.
Jay Rodriguez scored the game winning goal for Southampton in a 1-0 win over Crystal Palace.
Pepe Mel continues his horrid start as manager of West Bromwich Albion, now having gone winless in seven contests after a 0-3 loss in front of the Baggies supporters.
Wayne Rooney turned in a vintage performance, helping Manchester United to a rare convincing win, as he provided a goal and an assist in a tidy 0-3 win over West Bromwich Albion.
David Luiz will face a late fitness test before Chelsea face Tottenham on Saturday.
Ashley Cole is expected to miss around 10 days with a knee problem that he picked up during international duty this week.
Crystal Palace top scorer Marouane Chamakh faces a fitness test on the hamstring he injured at Swansea.
Kostas Mitroglou's honeymoon with Fulham continues to go horribly wrong, as he suffered another injury setback while on international duty for Greece in midweek, making him extremely unlikely to start against Cardiff City this weekend.
A knee injury sustained by Damien Duff three weeks ago will likely cause the veteran midfielder to miss the rest of the season for Fulham.
Tim Sherwood has revealed a number of injury concerns ahead of Tottenham's trip to fact Chelsea at Stamford Bridge.
Christian Eriksen insists he would not seek a move away from Tottenham if Tim Sherwood's side fail to finish in the top four this season.