Troy Deeney was given a rest last weekend over concerns about his fitness but he should be ready for a quick return to the starting eleven at Selhurst Park.
Gareth McAuley is definitely out for Week 26 with a hamstring injury and Jonny Evans, Craig Dawson and Chris Brunt are all doubtful as well.
Jon Walters was a late scratch with a virus last weekend but he should be available again for Week 26.
Week 26 will come too soon for Ryan Shawcross in his recovery from a significant back injury but he should be available for Week 27 in two weeks time.
While there weren't many details, Louis Van Gaal said that there was a "light at the end of the tunnel" for long term absentees Antonio Valencia and Marcos Rojo.
Phil Jones suffered a setback in his recovery from an ankle injury during Manchester United's 7-0 U21 league victory of Norwich on Monday.
Chelsea manager Guus Hiddink confirmed Diego Costa suffered a broken nose in training on Thursday and is currently being assessed ahead of the weekend.
Manchester City have avoided an injury crisis in midfield for at least this weekend after David Silva was passed fit to face Spurs this weekend in a matchup of No. 2 vs. No. 3 at the Etihad.
Manchester City will finally see the return of its captain after Vincent Kompany was cleared to make his first appearance of 2016 after a persistent calf injury.
Joe Allen will be "out for a while" according to Liverpool manager Jurgen Klopp, as the midfielder has to recover from a hamstring injury picked up last weekend.
Jurgen Klopp revealed that Dejan Lovren will be left out of action this weekend when Liverpool travel to play Aston Villa.
Max Gradel has returned to the club and is beginning the early stages of training as he looks to regain his fitness after a lengthy layoff following knee surgery.
Jack Colback has been training all week according to Steve McClaren and is available for selection when Newcastle United travel this weekend to take on Chelsea.
Sunderland have terminated the contract of Adam Johnson after he plead guilty to two charges related to sexual activity with a 15-year-old girl.
West Ham has moved to ensure that their star man remains the headline attraction as the Hammers move into the Olympic Stadium starting next season.