Sean Doolittle stemmed the tide of a five-run Astros comeback attempt to earn his 15th save in Wednesday's win.
Jesse Chavez got back in the win column by allowing two earned runs on four hits over 5 1/3 innings Wednesday in a 9-7 victory over the Astros.
Brad Peacock surrendered seven runs in 3 2/3 innings as the Astros lost in Oakland on Wednesday.
Yoenis Cespedes homered twice and drove in five runs before leaving Wednesday's game against the Astros with an apparent left thumb injury.
Tommy Medica went 3-for-5 with a double and two RBI in the Padres' 8-3 defeat of the Cubs on Wednesday.
Tsuyoshi Wada took a loss Wednesday after giving up five runs in four innings versus the Padres.
Huston Street picked up his first save as an Angel -- and his 25th save of the season -- in Wednesday's 3-2 victory over the Orioles.
Jeff Francoeur went 1-for-3 with an RBI and a walk as the Padres' right fielder in his debut Wednesday.
Albert Pujols went 2-for-4 with a double and an RBI in a win against the Orioles on Wednesday.
Jered Weaver limited the Orioles to two runs on six hits over eight innings Wednesday in a 3-2 win.
Chris Tillman tossed six innings of one-run ball Wednesday in a no-decision against the Angels.
Alex Cobb struck out 10 in seven innings Wednesday in the Rays' 3-0 victory over the Cardinals.
Jake McGee struck out the side in the ninth for his ninth save Wednesday against the Cardinals.
Desmond Jennings went 3-for-5 with a double and two runs scored as the Rays' leadoff hitter on Wednesday.
Jose Bautista homered and doubled to lead the Blue Jays past the Red Sox 6-4 on Wednesday.