Injuries to both first and second choice left-backs could hand Sam McQueen his first Premier League start for Southampton.
Southampton gave Leicester plenty to think about over the course of 90 minutes, but they could not find a goal and lost to the Foxes, 1-0.
Southampton have ramped up their search for a defender after conceding five goals in the first two matches.
Matt Targett is probable for gameweek 26 after recovering from a concussion.
Matt Targett will miss the midweek clash with West Ham United due to a slight concussion he picked up over the weekend.
Matthew Targett started in place of the suspended Ryan Bertrand but clashed heads with a Sunderland player and was forced off after 25 minutes.
Southampton are willing to let youngster Matt Targett earn a starting spot as a replacement of Luke Shaw.