Wes Brown was controversially sent off as Sunderland were defeated 2-0 by Stoke City.
Gus Poyet is likely to name the same side that beat Manchester City 1-0 against fourth-bottom Stoke City.
Winger Adam Johnson says Wes Brown's return from two years of injury has been key to Sunderland's recent form.
Wes Brown is hoping to step up his return from injury by starting Sunderland's Capital One Cup clash with Southampton on Wednesday with an aim of breaking back in to the first team.
Sunderland boss Gus Poyet has hinted he is considering turning to Wes Brown to shore up his side's defence for this weekend's Wear-Tyne derby.
Sunderland winger Adam Johnson has described defender Wes Brown's return to first-team action this summer as being "like a new signing".