Sunderland manager David Moyes confirmed both Sebastian Larsson and Lee Cattermole could return in the next month.
Sunderland's starting duo of Lee Cattermole and Steven Pienaar missed the club's 1-1 draw with West Brom due to injury.
Sunderland midfielder Lee Cattermole and winger Steven Pienaar have been cleared for the weekend match with Spurs.
Injuries to Lee Cattermole, Jan Kirchhoff and Seb Larsson meant that David Moyes was forced into using John O’Shea as a makeshift midfielder at the Etihad on Saturday.
Lee Cattermole will miss this weekends’ visit to Southampton after the tough tackling midfielder was forced off against Crystal Palace due to a head injury.
Just two weeks after declaring the squad fully fit, Sam Allardyce will have to find another way to remedy his injured midfield following blows to Sebastian Larsson and Lee Cattermole.
Sunderland will have to face Southampton in Week 12 without Lee Cattermole after the midfielder was ruled out with a groin injury.
Sunderland manager Sam Allardyce is hopeful the upcoming international break will cure the club of its injury woes after Lee Cattermole was subbed off in the first half against Everton with a knock.
Lee Cattermole made a first half exit in the Everton v Sunderland match after picking up a knock.
Lee Cattermole will serve a two match suspension for picking up his 10th yellow card of the season in Sunderland's 1-1 draw with Hull.
Sunderland boss Gus Poyet will ring the changes as the Black Cats entertain Leeds at the Stadium of Light on Sunday in the third round of the FA Cup.
Sunderland's Lee Cattermole scored a stunning goal as Sunderland drew 2-2 with West Brom at the Hawthorns.
Lee Cattermole is an early doubt for Sunderland's match on Sunday after limping off during the midweek match against West Brom.
Brighton midfielder Liam Bridcutt has become Sunderland’s fifth signing of the January transfer window.