The Manchester United center back left last weekend's loss to Stoke City with a calf injury and he will not recover in time for United's Week 25 match against Fulham.
Jonny Evans was substituted early in Manchester United's loss to Stoke City with what appeared to be a calf injury.
Jonny Evans is still dealing with a back issue and his ability to start against Arsenal on Sunday is yet to be determined.
Jonny Evans was withdrawn from United's match with Fulham on Saturday and missed training on Monday.
David Moyes continues to struggle with his selections in the center of defense with Jonny Evans partnering Phil Jones in the 1-1 draw with Southampton.
After having a place on the bench for the Manchester Derby, Jonny Evans made his first start back from injury in the Capital One Cup against Liverpool on Wednesday.
Manchester United defender Jonny Evans edged closer to a return as he was fit enough for a place on the bench against Bayer Leverkusen.