Phil Jones, who was exceptional against Arsenal in Week 11, will miss United's trip to Cardiff in Week 12.
Phil Jones has returned to Manchester United for treatment on a groin injury he picked up while with England this week.
Phil Jones and Jonny Evans have paired in United's central defense in recent weeks but they have been anything but water-tight thus far.
Phil Jones recovered from his injuries to start as a holding midfielder for Manchester United against Liverpool in the Capital One Cup.
Phil Jones took a knee to the back against Chelsea on Monday but is likely to be ready by Sunday for the trip to Liverpool.