Alex Oxlade-Chamberlain is in danger of missing the entire festive fixture programme after limping off at the Etihad on Sunday due to a muscular problem.
Alex Oxlade-Chamberlain scored a goal on either half of the interval as Arsenal beat Reading 2-0 at the Emirates.
Arsène Wenger will err on the side of caution as Alex Oxlade-Chamberlain continues his recovery from a serious knee injury.
Arsenal traveled to the north of France for their pre-season opener and drew 1-1 with Lens on Friday.
With his career at Arsenal stalled, Alex Oxlade-Chamberlain could look for a move to Leicester City this summer.
Alex Oxlade-Chamberlain re-injured his knee during his return from his previous knee injury and will miss both Arsenal's final two matches and the European Championships.
Alex Oxlade-Chamberlain reportedly injured both his knee and ankle in Arsenal's 2-0 loss to Barcelona at the Emirates on Tuesday and is likely out for the rest of the season.
Arsenal is waiting for the results of a scan on Alex Oxlade-Chamberlain after leaving yesterday's match with Barcelona due to a leg injury.
Arsenal defended stoutly for as long as they could but just couldn't keep Barcelona out as the Catalans eventually overwhelmed the Gunners 2-0 at the Emirates.
Mesut Ozil and Alex Oxlade-Chamberlain scored 88 seconds apart to account for the only two scores of the day as Arsenal secured a tidy 0-2 against AFC Bournemouth.
Will Theo Walcott's failure to track back against Olympiakos lead to him being benched for the visit of Manchester City?
Arsenal's attack continues to recover as Alex Oxlade-Chamberlain has been declared fit in addition to Aaron Ramsey who returned in mid-week as a substitute.
Alex Oxlade-Chamberlain's hamstring strain has caused two issues for Arsenal going into Week 11 with the Ox and the man who came in for him, Theo Walcott, both out for the trip to the Liberty Stadium.
Alex Oxlade-Chamberlain may miss out on his big chance to feature with Aaron Ramsey injured as he went off in the 5th minute of Arsenal's Capital One Cup match with Sheffield Wednesday.