There is concern among the Wizards organization that Nene may have torn a knee ligament on Sunday, according to Wizards beat writer Michael Lee.
Nene suffered a left knee sprain on Sunday night and will not return.
Nene hurt his left knee in the third quarter of Sunday's game and went to the locker room.
Nene not only hit 13-of-19 shots to tie his season high with 30 points on Saturday, but flushed home the game-winning dunk on a pass from John Wall with 0.3 seconds left in the game.
Nene scored 21 points against the Rockets on Wednesday with one board, one assist and one steal in 30 minutes.
Nene scored 17 points against the Grizzlies on Tuesday during a tough 92-89 loss to go with four boards, three assists, three steals and one block in 36 minutes.
Nene was one of five Wizards players in double-figures during Sunday's win vs. the Kings, as he finished with 18 points, five rebounds, five assists, two steals and three blocks.
Nene hit 7-of-15 shots for 14 points, eight rebounds, six assists and two steals on Wednesday.
Nene had 16 points, seven rebounds, two assists, two steals and a block on 7-of-15 shooting in Tuesday's win over the Warriors.
Nene turned the ball over a season-high six times against the Suns on Friday during a 101-95 win with 18 points, eight boards, two assists, one steal and one block in 33 minutes.
Nene bounced back from an ugly game on Monday, scoring 17 points on Wednesday with nine boards, three assists, one steal and one block in 34 minutes.
Nene slowed down against the Sixers on Monday with seven points, five boards, two assists, two steals and two blocks in 23 minutes.
Nene hit 6-of-15 shots for 19 points, four rebounds, nine assists, two steals and three blocks in his second consecutive start for the Wizards on Wednesday.
Nene (Achilles) made his first start since his injury and is enjoying his return to the Wizards starting lineup.