In Week 16, the Indianapolis defense will face the slumping Miami offense that has averaged just 271.2 total yards in the last five weeks.
The Indianapolis defense has allowed an astonishing 96 points over the last two weeks.
The Indianapolis Colts travel to Pittsburgh in Week 13 to face the Steelers, who are fourth among NFL offenses in total yardage.
Indianapolis' 29th-ranked pass defense will take on Tampa Bay rookie QB Jameis Winston in Week 12.
The Indianapolis Colts will enjoy a bye in Week 10 but face the Atlanta Falcons in Week 11, who are fifth among NFL offenses with an average of 402.2 total yards per game.
The Indianapolis defense is 28th among NFL teams in run defense, allowing 124.9 yards per game this season.
The Indianapolis Colts travel to Carolina on Monday to face the Panthers and the NFL's leading rushing attack.
The Indianapolis Colts are 29th in total defense this season, allowing 401.8 total yards per game.
The Indianapolis Colts D/ST will not be a viable Week 6 fantasy option as they host the New England Patriots.
The Indianapolis Colts will face the Houston Texans and struggling quarterback Ryan Mallett in Week 5.
Indianapolis is set to face Tennessee quarterback Marcus Mariota, who was sacked seven times in Week 2 at Cleveland.
The Indianapolis defense will be without two of their top three cornerbacks on Monday night against the New York Jets.
The Indianapolis Colts traded for defensive lineman Billy Winn to boost their depth along the defensive line.
The Indianapolis Star tabbed rookie Henry Anderson as a player who could help contribute on the Colts defensive line after losing DT Arthur Jones to an ankle injury.