Detroit will host Chicago QB Matt Barkley in Week 14, who has managed to completed just 51.7 percent of his pass attempts in 2016.
The Detroit defense will look to repeat its Week 9 performance against Minnesota when the NFC North rivals meet on Thursday.
Detroit LB DeAndre Levy (knee) returned to practice on Wednesday for the first time since Week 1.
The Detroit defense is last in the NFL in third-down defense, allowing conversions at a 51.2 percent clip.
Detroit DE Ziggy Ansah (ankle) is expected to play on Sunday, his first action since Week 2.
The Detroit defense will take on Chicago QB Brian Hoyer on Sunday, with Jay Cutler (thumb) listed as doubtful for Week 4.
Detroit linebacker DeAndre Levy missed practice on Wednesday due to a quadriceps injury.
The Detroit Lions will travel to Chicago in Week 17 to face the Bears, who will be missing star wide receiver Alshon Jeffery (hamstring).
The Detroit defense has a date with San Francisco QB Blaine Gabbert in Week 16.
The Detroit defense has improved in pass defense recently, allowing just 170.8 passing yards per game over the last four weeks.
The Detroit Lions travel to St. Louis in Week 14 to take on the struggling Rams offense.
The Detroit Lions have allowed just 195.5 passing yards per game over their last four contests.
The Detroit defense has not forced a turnover since Week 7.
The Detroit Lions will host the Oakland Raiders in Week 11, who have averaged 30 points per game over the last four weeks.