The Detroit defense has a date with San Francisco QB Blaine Gabbert in Week 16.
The Detroit defense has improved in pass defense recently, allowing just 170.8 passing yards per game over the last four weeks.
The Detroit Lions travel to St. Louis in Week 14 to take on the struggling Rams offense.
The Detroit Lions have allowed just 195.5 passing yards per game over their last four contests.
The Detroit defense has not forced a turnover since Week 7.
The Detroit Lions will host the Oakland Raiders in Week 11, who have averaged 30 points per game over the last four weeks.
The Detroit Lions, who are last in the NFL in scoring defense, will travel to Green Bay in Week 10 to face the Packers.
The Detroit Lions are dead last among NFL teams in scoring defense, surrendering 30.6 points per game.
The Detroit Lions have struggled to contain opposing quarterbacks in 2015, allowing a 73.3 completion percentage and NFL-worst 9.1 yards per pass attempt.
The Detroit defense could be getting a key piece back this week, as DT Haloti Ngata (calf) returned to practice on Wednesday.
The Detroit Lions defense will face the NFL's second-highest scoring offense this week when they host the Arizona Cardinals at Ford Field.
The Detroit Lions may be facing the Seattle Seahawks without star running back Marshawn Lynch on Monday while he deals with a hamstring injury.
DT Caraun Reid will make his 2015 debut on Sunday after missing the first two weeks of the season with an ankle injury.
The Detroit Lions allowed 404 passing yards to Chargers quarterback Philip Rivers in Week 1 as they fell to San Diego 33-28.