The Titans will face one of Indianapolis' many backup quarterbacks in Week 17 with Andrew Luck, Matt Hasselbeck, and Charlie Whitehurst injured.
With QB Brian Hoyer dealing with a concussion, the Houston Texans will likely be led by QB Brandon Weeden in Week 16 against Tennessee.
The Tennessee defense has forced just five turnovers in the last five weeks while allowing 27.8 points per game.
Tennessee CB Perrish Cox was tabbed as a key player for the Titans in Week 14 by the Nashville Tennessean as he is expected to spend time covering Brandon Marshall.
Tennessee has allowed more than 100 rushing yards just once since Week 7.
The Tennessee defense has racked up 13 sacks over the last three weeks.
The Nashville Tennessean tabbed LB Brian Orakpo as one of the keys to Thursday's game between Tennessee and Jacksonville.
The Tennessee Titans will face the Carolina Panthers and their league-leading rushing attack in Week 10.
The Tennessee defense could be without cornerback Jason McCourty on Sunday, who is dealing with a groin injury.
The Tennessee Titans will be facing a committee of Houston running backs when they take on the Texans without RB Arian Foster.
The top-ranked pass defense of the Tennessee Titans will face Matt Ryan and the Atlanta Falcons in Week 7.
The Tennessee Titans will face the Miami Dolphins in Week 6, who rank 28th among NFL teams with an average of 314.8 total yards per game this season.
With LeSean McCoy (hamstring) and Karlos Williams (concussion) ruled out for Week 5, the Tennessee Titans will face running backs Anthony Dixon and Dan Herron on Sunday.
The Tennessee Titans will enjoy their bye week in Week 4, with the DC Ray Horton's group having success against opposing quarterbacks through the first three weeks.