The Arizona defense allowed 208 rushing yards to the Buffalo Bills in Week 3, and are 28th in NFL run defense through three weeks.
The Cardinals D/ST will face an understaffed Patriots offense on Sunday night as TE Rob Gronkowski (hamstring), T Nate Solder (hamstring), and RG Jonathan Cooper (foot) have all been ruled out.
The Arizona defense has forced 11 turnovers in the last three weeks.
The Cardinals defense will play without DB Tyrann Mathieu for the first time this season when the Green Bay Packers visit Arizona in Week 16.
The Arizona Cardinal have held six of their last seven opponents under 100 rushing yards.
Arizona will host the Minnesota Vikings on Thursday night, who managed just 125 total yards of offense in Week 13.
The Arizona defense gets a favorable Week 13 matchup at St. Louis, who will be led by struggling quarterback Nick Foles.
The Arizona defense will face 49ers QB Blaine Gabbert in Week 12 when they travel to San Francisco.
The Arizona Cardinals will host the Cincinnati Bengals in Week 11, who registered their worst offensive performance of the season in Week 10.
Fox Sports Arizona lists the ability to "slow down Jimmy Graham" as a key to Week 10 for the Arizona defense.
The Arizona defense is tied for the NFL lead in interceptions, picking off 13 passes through eight games.
The Arizona defense will be without CB Jerraud Powers (hamstring) on Sunday, giving CB Justin Bethel his first career start.
The Arizona D/ST will look to bounce back from a disappointing effort in Week 6 when they host the Baltimore Ravens on Monday night.
The Arizona defense will get linebacker Dwight Freeney involved in Week 6 after signing the veteran this week.