Buffalo will host the Cleveland Browns in Week 15, who have managed just 9.8 points per game since Week 8.
The Buffalo Bills will rely on rookie CB Kevon Seymour to fill-in for CB Ronald Darby (concussion) in Week 13.
The Buffalo defense has allowed seven plays of 50 yards or more this season.
The Buffalo Bills will get rookie LB Shaq Lawson (shoulder) back in Week 7 after spending six weeks on the PUP list.
The Buffalo defense has recorded eight sacks and forced six turnovers over the last two weeks.
NY Jets QB Ryan Fitzpatrick has a 47 percent completion percentage in 11 games against Rex Ryan defenses in addition to a 1-8 record as a starter.
The Buffalo defense is expected to get CB Ronald Darby (groin) back from injury in Week 17.
The Buffalo defense will face Dallas quarterback Kellen Moore in Week 16.
The Buffalo defense has worked in practice to prepare for the quick pace of Philadelphia's offense.
The Buffalo defense has just 16 sacks this season and four over the last five weeks.
The Buffalo Bills travel to New England in Week 11 to face the NFL's highest-scoring offense.
The Buffalo News noted the defensive line of the Bills as the "face and voice of the frustration and disappointment" of the Buffalo defense through the first half of the season.
The Buffalo Bills will be looking for an improved pass rush as they take on Miami in Week 9.
The Buffalo defense is struggling of late, allowing 68 points over the last two weeks.