Cincinnati MLB Rey Maualuga (leg) is expected to be sidelined Monday night when the Bengals face the New York Giants.
The Cincinnati defensive front will look to take advantage of a banged up Cleveland offensive line on Sunday.
Cincinnati will welcome the return of suspended linebacker Vontaze Burfict on Thursday night.
The Cincinnati defense is last among NFL teams in run defense through two weeks, allowing 138.0 yards per game and 4.2 yards per carry.
The Cincinnati Bengals allowed 113 rushing yards in Week 16, the first time the team had allowed over 100 yards on the ground since Week 8.
The Cincinnati defense, the NFL's top-ranked scoring unit, will travel to Denver on Monday to face the Broncos.
The Cincinnati defense faces the NFL's most sacked team in Week 15, the San Francisco 49ers.
The Cincinnati Bengals lead the NFL in scoring defense, allowing 16.3 points per game and have held five of their last six opponents to 10 points or less.
With quarterback Josh McCown (collarbone) out, the Cleveland Browns will start Austin Davis against Cincinnati in Week 13.
The Cincinnati Bengals will put their 13th-ranked run defense to the test in Week 12 against St. Louis running back Todd Gurley.
The Cincinnati defense has allowed just 30 total points over the last three weeks.
The Cincinnati defense is preparing to face star Houston wide receiver DeAndre Hopkins on Monday night.
The Cincinnati Bengals will face Cleveland QB Johnny Manziel on Thursday night.
The Cincinnati defense will face Pittsburgh quarterback Ben Roethlisberger in Week 8 as he returns from a knee injury.