The 49ers are on track to allow 2,789 rushing yards this season, which would be the most since the Houston Oilers gave up 2,814 in 1985.
The San Francisco defense will face Arizona QB Drew Stanton on Thursday with Carson Palmer (concussion) ruled out.
The San Francisco defense has forced six turnovers through two weeks of the 2016 season.
The San Francisco 49ers have forced just 12 turnovers in 15 games this season.
The San Francisco 49ers will face Cincinnati quarterback A.J. McCarron in Week 15 with Andy Dalton (thumb) out.
The San Francisco defense will face Cleveland QB Johnny Manziel in Week 14.
The San Francisco defense has forced just eight turnovers in 11 games, the second-worst mark among NFL defenses.
San Francisco LB Ahmad Brooks is going through the NFL concussion protocol this week and did not practice on Thursday.
The San Francisco defense will attempt to improve upon their Week 7 performance against the Seahawks when the team travels to Seattle in Week 11.
The San Francisco defense heads into their Week 10 bye in the bottom-five among NFL defenses in passing yards allowed per game, completion percentage, and yards per attempt from opposing passers.
The San Francisco defense has a tough Week 9 matchup on tap as the Atlanta Falcons travel to Levi's Stadium to face the 49ers.
The San Francisco defense will face a tough task in Week 8 as they look to corral St. Louis running back Todd Gurley.
The struggling San Francisco defense will face the Seattle Seahawks at home on Thursday night.
The San Francisco 49ers are tied for 32nd among NFL teams with just two forced turnovers through four weeks.