According to the NFL Network, Ryan Mathews' sprained MCL could keep him out 4-5 weeks.
The Union-Tribune San Diego confirms the "initial prognosis" for Ryan Mathews' right knee injury is a sprained MCL.
Ryan Mathews is headed for an MRI on his right knee.
Ryan Mathews was carted off the field in San Diego's Week 2 game against the Seahawks with an apparent right knee/leg injury.
Ryan Mathews rushed for 40 yards and one touchdown on 12 carries in Monday night's Week 1 loss to the Cardinals.
Ryan Mathews rushed for 22 yards on four carries in Sunday's third preseason game against the 49ers.
Ryan Mathews is inactive for Friday night's preseason game.
Coach Mike McCoy said after Thursday's preseason opener that he's going to keep feeding Ryan Mathews the ball following his fumble at the goal line.
Ryan Mathews rushed five times for 19 yards in the Chargers' preseason opener Thursday night against the Cowboys.
Ryan Mathews is referring to the Chargers' backfield as "the three-headed monster."
ESPN Chargers reporter Eric Williams believes walk-year RB Ryan Mathews could be headed into his final season in San Diego.
According to the Union-Tribune San Diego, Ryan Mathews weighed 227 pounds at Chargers minicamp, down nine pounds from that time last year.
Chargers OC Frank Reich said Ryan Mathews will remain the main back in San Diego.
ESPN's Eric D. Williams said the Chargers will continue to "lean on" the running game this season.