The Steelers will likely face either Jimmy Clausen or Ryan Mallett at quarterback in Week 16 when they travel to Baltimore.
The Pittsburgh defense will look to take advantage of the Denver offensive line that allowed five sacks in Week 14.
Pittsburgh has allowed over 300 passing yards in three of their last four contests.
With Seattle running back Marshawn Lynch (sports-hernia surgery) ruled out, the Pittsburgh defense will attempt to corral rookie RB Thomas Rawls on Sunday.
The Pittsburgh Steelers have been successful while rushing the passer in 2015, with the help of their linebacker rotation.
The Pittsburgh defense faces an intriguing home matchup with Cleveland in Week 10, who is 29th in scoring offense at 19.7 points per game.
The Pittsburgh defense has struggled with pass defense in 2015, allowing opposing passers to throw for 276.9 passing yards per game with a 68.8 completion percentage.
The Pittsburgh Steelers travel to Kansas City to face the Chiefs on Sunday, who are struggling to run the ball without Jamaal Charles.
The Pittsburgh Steelers will host the Arizona Cardinals in Week 6, who lead the NFL in scoring through five weeks.
The Pittsburgh Steelers will look to improve against the run on Monday night when they face the San Diego Chargers.
The Pittsburgh Post-Gazette listed the matchup between Baltimore wide receiver Steve Smith Sr. and Pittsburgh safety Mike Mitchell as a key to Thursday's game.
The Pittsburgh defense will be without productive LB Ryan Shazier in Week 3, as he deals with a shoulder injury.
The Pittsburgh Steelers will attempt to slow down the emerging running game of the San Francisco 49ers in Week 2.
The Pittsburgh Steelers defense failed to record a turnover and sacked Patriots quarterback Tom Brady just twice in Week 1.