Pittsburgh DC Keith Butler plans on using a variety of defensive schemes to limit Buffalo QB Tyrod Taylor's rushing impact.
With QB Andrew Luck (concussion) ruled out, the Steelers D/ST will face backup QB Scott Tolzien on Thursday.
The Pittsburgh Steelers are preparing to face Dallas RB Ezekiel Elliott in Week 10.
The Pittsburgh secondary has yet to record an interception through seven weeks.
Pittsburgh DE Cam Heyward will miss at least the next two weeks with a hamstring injury.
The Pittsburgh defense has allowed just 101 total rushing yards through two weeks, the second-best mark in the NFL.
The Pittsburgh defense will likely face Cleveland quarterback Austin Davis in Week 17 as Johnny Manziel deals with concussion issues.
The Steelers will likely face either Jimmy Clausen or Ryan Mallett at quarterback in Week 16 when they travel to Baltimore.
The Pittsburgh defense will look to take advantage of the Denver offensive line that allowed five sacks in Week 14.
Pittsburgh has allowed over 300 passing yards in three of their last four contests.
With Seattle running back Marshawn Lynch (sports-hernia surgery) ruled out, the Pittsburgh defense will attempt to corral rookie RB Thomas Rawls on Sunday.
The Pittsburgh Steelers have been successful while rushing the passer in 2015, with the help of their linebacker rotation.
The Pittsburgh defense faces an intriguing home matchup with Cleveland in Week 10, who is 29th in scoring offense at 19.7 points per game.
The Pittsburgh defense has struggled with pass defense in 2015, allowing opposing passers to throw for 276.9 passing yards per game with a 68.8 completion percentage.