Alexis Sanchez scored a precision free kick to put Arsenal ahead 1-0 in the first half but Southampton scored twice to win at the Emirates and boot Arsenal from the competition.
Mesut Ozil and Danny Welbeck each had a goal and an assist in Arsenal's 3-0 win over Aston Villa on Saturday.
Arsenals’ misery was compounded in Dortmond last night as Jack Wilshere suffered ANOTHER ankle injury but his absence could see Mesut Ozil revert back to his preferred central role.
Nacho Monreal became the latest Arsenal defender to be sidelined after the player suffered a minor back injury during Saturday’s home draw with Manchester City. The Spanish full-back did not travel with the rest of the squad to Germany where the Gunner’s face Borussia Dortmond in their opening Champions League game on Tuesday.
Laurent Koscielny took the top spot on this week's Joel Ward All-stars with a stout defensive performance despite Arsenal giving up two goals to Manchester City.
Aaron Ramsey continued to delivery great all-around performances for Arsenal with 16 point performance in the Yahoo format in Week 4.
Alexis Sanchez continued his strong start to his Arsenal career with his third goal in his last four matches across all competitions for Arsenal.
Danny Welbeck experienced some cramping in his Arsenal debut but should be OK going forward.
Good news for Arsenal fans, Mathieu Debuchy has a bad ankle sprain and doesn't have any broken bones.
Jack Wilshere staked his claim to a starting spot in Arsenal's midfield with a goal and an assist as part of an exceptional overall performance in a scintillating 2-2 draw at the Emirates.
Mesut Ozil is ready to go for Arsenal after returning from international duty early with an ankle sprain.
Danny Welbeck is fit and highly likely to start in the number nine role for Arsenal against Manchester City on Saturday in the early match.
While certainly not a lock to start, Arsenal supporters will be boosted by reports that Aaron Ramsey trained with the team on Friday ahead of Saturday's clash with Manchester City.
Kieran Gibbs is back to full training and is sufficiently fit to face Manchester City as they come to the Emirates in Week 4 action.
Mikel Arteta is back in training and fully fit to participate in Arsenal's big match against Manchester City on Saturday.