Jordon Ibe has been ruled out for between 3-4 weeks after the Liverpool youngster damaged lateral knee ligaments during last Thursdays’ Europa League game against Besiktas.
Alan Hutton will miss Aston Villa's next two matches due to being booked once again.
Saido Berahino's goal wasn't enough for West Brom as they went down to a last minute defeat at rivals Aston Villa.
Christian Benteke's last-gasp penalty gave Tim Sherwood his first points as Aston Villa manager with victory over West Brom at Villa Park.
Jack Rodwell was in the middle of just about everything as Sunderland came from a goal down to draw 1-1 with Hull City at the KC Stadium.
A Sadio Mane late goal gave Southampton three points over Crystal Palace.
Dame N'Doye returned to the Hull City starting line-up in Week 28 and made a major impact but couldn't power his team to victory as they drew with Sunderland 1-1.
Kieran Richardson and Aly Cissokho will both miss out on a second consecutive match as Aston Villa host Midlands rivals West Brom on Tuesday.
Jon Walters' ongoing knee issues may keep him out of Stoke City's Wednesday match with Everton in Week 28.
Luke Shaw was rested over the weekend due to ongoing tightness in his hamstrings but should be available for Manchester United's trip to Newcastle on Wednesday.
Phil Jones missed the visit of Sunderland over the weekend with an illness but should be ready to go again for the mid-week trip to St. James' Park.
After being rested for Week 27 against Everton, Per Mertesacker may be rested again for Week 28 in order to give him an extended rest.
Francis Coquelin is questionable for Arsenal's trip across London after suffering a head injury in a collision with Olivier Giroud in the 2-0 over Everton on Sunday.
Dame N'Doye was rested due to fatigue after having to travel back and forth to Senegal last week. He is questionable for Week 28 but seems likely to play having had two more days to recover.
Nikica Jelavic who missed Hull City's Week 27 loss has a chance to feature in Week 28 with his manager saying that he's "hopeful".