Dusan Tadic started Southampton's match from the bench this weekend.
Graziano Pelle will miss the Week 14 trip to the Etihad due to an accumulation of yellow cards.
Southampton have confirmed that striker Jay Rodriguez will go under the knife on Tuesday to remedy a niggling foot problem which has hampered the 26-year-old recently.
Maarten Stekelenburg was the most prominent Saints player as he made a few solid saves but couldn't keep out the one goal that mattered.
Southampton boss Ronald Koeman has confirmed that Jay Rodriguez is likely to need surgery to cure a persistent foot problem.
Ryan Bertrand is hoping to get a chance to impress England Boss Roy Hodgson in order to cement his place in the England Euro 2016 squad, according to Sky Sports.
Southampton defender Virgil van Dijk is expected to be OK for the visit of Stoke in game week thirteen after the Dutch defender was withdrawn as a precaution during the win over Wales.
The Southampton winger scored his fourth goal of the season—a 69th-minute penalty kick—to leave the Northeast with a close win against struggling Sunderland.
Ronald Koeman confirmed during Sundays’ post-match press-conference that defender Jose Fonte had been withdrawn at half-time due to "pain in his hamstring."
Goals in the first half from Steven Davis and Graziano Pelle put Southampton in a comfortable position to defeat AFC Bournemouth, 2-0.
Jay Rodriguez will miss this weekend's clash against Bournemouth.
Shane Long has been ruled out for gameweek 11.
Sadio Mane had an interesting match in Southampton's 1-1 draw against Liverpool by both scoring and getting sent off in a matter of just 10 minutes.
Jay Rodriguez was a notable absentee from the Southampton squad which arrived at Anfield for the final Premier League match of game week ten.
Veteran goalkeeper Kelvin Davis came in for his first PL start of the campaign - against Leicester - after Maarten Stekelenburg picked up an injury in training.