Shane Long will be assessed after the Republic of Ireland forward was stretchered off during Sundays' Euro qualifying defeat in Poland.
Ronald Koeman has warned Southampton fans that they may one day lose Sadio Mane.
Sadio Mane and Graziano Pelle combined to down Chelsea in a a huge 3-1 victory at Stamford Bridge.
Ronald Koeman expects to name the same squad for the trip to Stamford Bridge on Saturday, however one potential change could be the addition of Jordy Clasie who has recovered from recent hamstring and ankle injuries.
Ryan Bertrand is huge for Southampton according to team captain Jose Fonte.
Virgil van Dijk opened his Southampton account by scoring the Saints first goal of the day, and they would eventually cruise to a 3-1 win over Swansea City.
Jordy Clasie will have a chance to return in week eight against Chelsea.
Steven Caulker has returned to Southampton's squad after battling a sinus infection last week.
Ryan Bertrand could return in gameweek 7 but "may not be ready for a full match".
Pelle is expected to recover from the minor foot problem in time for the visit of Swansea this weekend "Graziano did a normal session today [Thursday] and he will be ready for Saturday."
Anthony Martial has been electric since his arrival at Manchester United and there's no doubt it will continue if he continues to get gifts the likes of the one presented to him by Maya Yoshida.
Ryan Bertrand has been ruled out for week six.
Southampton's Sadio Mane is expected to start this weekend after being left on the bench last week.
Jordy Clasie continues to miss time and is not close to returning for Southampton.
Cuco Martina and Sadio Mane are considered questionable this weekend after returning late from international duty.