James Ward-Prowse hit the post in the in 70th minute but that was as close as either side got in a listless nil-nil draw at St. Mary's.
Ryan Bertrand could be a wise addition to your Yahoo fantasy defence as Southampton face West Brom in Week 2.
Ramirez missed the first week of the season through a groin injury and is now expected to be out for at least one more.
Southampton entered the season a major question mark after losing so many key players over the summer but, if today was any indication, look to have plenty of reason to be optimistic as they gave Liverpool plenty of trouble today despite losing in the end 2-1.
New Southampton signing Florin Gardos did not travel with the club due to a thigh injury.
Southampton boss Ronald Koeman is still undecided on whether to start Shane Long at Anfield on Sunday.
Morgan Schneiderlin may not feature in Southampton's week one match as there are continuous transfers rumors about him.
Southampton have signed Romanian defender Florin Gardos as a replacement for Dejan Lovren.
Shane Long has completed his second move of 2014 with news that the surprising switch from Hull City to Southampton has gone official.
The Mirror are reporting that Southampton and Hull City have agreed on a transfer fee for striker Shane Long.
Southampton are reportedly in the final stages of wrapping up the signature of Romanian center back Floran Gardos to replace the departed Dejan Lovern.
Southampton have continued to rebuild their squad with the purchase of England international Fraser Forster from Celtic.
Morgan Schneiderlin's future is once again in doubt as the midfielder has stated he's not "mentally or physically ready" to play.
Jose Fonte has signed a new deal at Southampton that will keep him at the club until 2017.
Southampton are looking to finalize a deal for England goalkeeper Fraser Forster.