Dusan Tadic started out the season well in fantasy but not well enough to keep his place in the starting line-up as he sits on the bench again in Denmark.
Victor Wanyama will miss Thursday's clash versus FC Midtjylland and is questionable for the weekend due to an illness.
Sadio Mane is a slight doubt for Southampton's match against Midtjylland on Thursday.
Sadio Mane endured a particularly bruising 25-minute spell at Vicarage Road on Sunday before injury forced his withdrawal.
Graziano Pelle put a high drive toward the top corner of the Watford goal but it was well saved by Heurelho Gomes to preserve the nil-nil draw at Vicarage Road.
Jay Rodriguez scored from the penalty spot in Southampton's 1-1 draw against Midtjylland.
Ronald Koeman claimed that Southampton will not sell any more players this transfer window.
Shane Long started for Southampton in place of Jay Rodriguez in week two.
Southampton have ramped up their search for a defender after conceding five goals in the first two matches.
The Southampton side that impressed so well in preseason and in early Europa action find themselves on only one point after two games with a 0-2 defeat to Everton today.
Steven Caulker has been ruled out for this weekend's match due to a sinus infection.
Jordy Clasie featured in Southampton's U21 team this past Monday but picked up a knock in the second half.
Southampton have moved to further sure up their holding midfield with a move for Chelsea's frequently loaned-out midfielder Oriol Romeu for £5million.
Ki Sung-Yueng had to make an early exit from Swansea's draw with Chelsea on Saturday with a pulled hamstring, but early diagnosis has the strain as minor, and the midfielder may not miss Week 2.
Jay Rodriguez started Southampton's first Premier League match of the season.