Rick Porcello gave up only two runs in a dominant complete game five-hitter to lead the Red Sox to a 6-2 victory over the Angels on Friday.
Xander Bogaerts smacked a two-run homer and added an RBI double in Friday's game.
Red Sox manager John Farrell indicated Friday that David Ortiz is likely to sit on Saturday.
Brad Ziegler is unavailable should a save situation arise on Friday against the Angels.
Travis Shaw is not in the Red Sox starting lineup for Friday night's tilt against Tim Lincecum and the Angels.
Brad Ziegler coughed up a 1-0 ninth-inning lead in Thursday's 2-1 loss to the Angels.
David Price was superb in earning a no-decision in Thursday's 2-1 loss to the Angels, rolling through eight shutout frames while scattering seven singles.
Red Sox manager John Farrell said he hasn't considered skipping Steven Wright's turn in the rotation despite his struggles with humid weather conditions.
Chris Young (hamstring) and Josh Rutledge (knee) could begin rehab assignments when the Red Sox return from their 11-game road trip.
Craig Kimbrel (knee) is on track to rejoin the Red Sox on Monday.
Eduardo Rodriguez surrendered three earned runs over 5 1/3 innings Wednesday in a no-decision against the Tigers.
Brad Ziegler allowed a go-ahead homer in the top of the ninth inning Wednesday as the Red Sox fell to the Tigers.
Red Sox SS prospect Jose Sermo blasted three homers Tuesday in a win for High-A Salem.
Hanley Ramirez is not in the Red Sox starting lineup Wednesday afternoon against the Tigers.
Steven Wright gave up eight runs in 4 2/3 innings Tuesday against the Tigers.