Tommy Milone shut out the White Sox for seven innings Wednesday to improve to 7-4.
Kevin Jepsen picked up his 10th save with Glen Perkins unavailable Wednesday.
Miguel Sano hit his 15th homer Wednesday off the White Sox's Carlos Rodon.
Phil Hughes (back) will throw a bullpen session on Thursday.
Glen Perkins was unavailable Wednesday due to back stiffness.
Aaron Hicks (hamstring) will rejoin the Twins on Friday.
Twins general manager Terry Ryan said pitching prospect Jose Berrios will not be called up before the end of the season.
Miguel Sano (hamstring) is in the Twins' starting lineup on Wednesday night against the White Sox.
Twins OF prospect Adam Brett Walker drilled his 30th home run Tuesday in a win for Double-A Chattanooga.
Glen Perkins returned to the closer role on Tuesday, allowing a run on three hits but earning the save in the Twins' 8-6 win over the White Sox.
Miguel Sano went 3-for-5 with a home run and two runs scored Tuesday against the White Sox.
Eduardo Escobar went 3-for-4 with an RBI and two runs scored in a win over the White Sox on Tuesday.
Tyler Duffey allowed three runs over 4 2/3 innings in a no-decision against the White Sox on Tuesday.
Twins minor leaguer Adrian Salcedo has been suspended 100 games after testing positive for the second time for Heptaminol, a stimulant.
Twins manager Paul Molitor said Tuesday that Jose Berrios could still be called up.