Francisco Liriano had a quality start but picked up a loss Wednesday, yielding three runs over seven frames against the Reds.
Pedro Alvarez went 0-for-3 with two strikeouts in Wednesday's loss to the Reds to drop his season batting line to .161/.277/.446.
Jose Tabata has been diagnosed with "mild" concussion-like symptoms.
Jose Tabata left Wednesday's game against the Reds after colliding with the left field wall.
Starling Marte is not in the Pirates' lineup Wednesday.
Gerrit Cole was hammered for five runs over six innings and took the loss in Tuesday's start against the Reds.
Neil Walker went 2-for-4 with a home run as the Pirates fell to the Reds on Tuesday.
Pirates manager Clint Hurdle admitted Tuesday that the club is keeping an eye on Wandy Rodriguez's velocity.
Jason Grilli struck out a pair in a scoreless inning to convert his fourth save of the season Tuesday as the Pirates finished off the Reds 8-7 in the completion of Monday's suspended game.
Neil Walker and Gaby Sanchez hit back-to-back homers twice Monday before the game between the Pirates and Cubs was suspended due to rain with the score 7-7 after six innings.
Wandy Rodriguez gave up six runs in five innings Monday versus the Reds.
Chris Stewart (knee) could be activated from the disabled list by this weekend.
Andrew McCutchen went 1-for-3 with an RBI in the Pirates' loss to the Brewers on Sunday.
Luis Heredia has been placed on the disabled list at Low-A West Virginia with a right shoulder injury.
Starling Marte scored the Pirates' only run in Sunday's loss to the Brewers.