Chargers ILB Manti Te'o fractured his foot in Week 3 against the Bills, and is expected to miss multiple weeks.
Danny Woodhead needs surgery on his fractured fibula and ankle and will be lost for the rest of the season.
Ladarius Green played on 23-of-69 snaps (33.3 percent) in Sunday's win at Buffalo.
A source tells FOX Sports that Danny Woodhead will likely need season-ending surgery on his ankle.
Eddie Royal caught four passes for 42 yards and two touchdowns against the Bills.
Malcom Floyd caught two passes for 98 yards against the Bills.
Ladarius Green caught 4-of-6 targets for 64 yards against the Bills.
Antonio Gates caught one pass for eight yards against the Bills Week 3.
Chargers coach Mike McCoy said Danny Woodhead (ankle) would undergo further testing on Sunday night.
Keenan Allen caught two passes for 17 yards against the Bills Week 3.
Branden Oliver only saw three carries against the Bills Week 3.
Donald Brown rushed 31 times for 62 yards and caught five passes for 27 yards against the Bills Week 3.
Philip Rivers completed 18-of-25 passes for 256 yards and two touchdowns against the Bills.
Danny Woodhead was carted off the field after suffering an ankle injury against the Bills.
RB Danny Woodhead has been listed as the starting running back for the Chargers against the Bills Week 3.