Mark Stone's undisclosed injury might be a high-ankle sprain.
Ottawa coach Paul MacLean reunited Jason Spezza with Daniel Alfredsson and Milan Michalek for Game 5.
It is too early to determine if Daniel Alfredsson has played his last NHL game.
Craig Anderson gave up six goals on 33 shots in Ottawa's 6-2 Game 5 loss to Pittsburgh on Friday night.
Kyle Turris scored and assisted for the Senators as their season came to an end with a 6-2 loss in Game 5 of their second-round series with the Penguins on Friday night.
Cory Conacher is playing for the Senators on Friday night.
Mark Stone did not make the trip to Pittsburgh for Game 5 because of an undisclosed injury.
Daniel Alfredsson feels his comment about the Senators not being able to rally from a 3-1 series deficit against Pittsburgh was taken out of context.
Obviously, Craig Anderson will be between the pipes for Ottawa Friday night in Game 5 at Pittsburgh.
Erik Karlsson collected two assists and five shots in Wednesday's 7-3 loss to Pittsburgh.
Andre Benoit picked up an assist Wednesday night.
Kyle Turris potted his team-leading fifth goal of the postseason in Wednesday's 7-3 loss to Pittsburgh.
Milan Michalek scored in Wednesday's 7-3 loss to Pittsburgh for the first time since Game 2 of the opening round against Montreal.
Mark Stone registered two shots in 11:23 of ice time for the Senators in Game 4 versus Pittsburgh.
Daniel Alfredsson isn't confident that Ottawa can come back from a 3-1 series deficit against Pittsburgh.